22. The prescription medication ProZinc may be injected once a day to reduce hyperglycemia and hyperglycemia-associated clinical signs in most diabetic dogs, according to the … By Company. PROZINC is an aqueous suspension of protamine zinc recombinant human insulin that is indicated to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus. Abstract EN10. Check Price ... A great option for pet owners who want an effective insulin as well as to save a bit of money treating their pets. ProZinc helps control blood glucose by stimulating carbohydrate metabolism in heart, bone and fat tissue, helping these cells to … For both cats and dogs, the symptoms of diabetes can include excessive thirst and urination, increased appetite and weight loss. Learn more about managing canine diabetes. Can dogs safely take it. Proin dosage for dogs. PROZINC is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus., 2 PROZINC®(protamine zinc recombinant human insulin) [Freedom of Information Summary]. ProZinc is contraindicated during episodes of hypoglycemia. For pets with diabetes, consistent routines that include insulin therapy, and lifestyle changes such as diet and physical activity, are critical to staying healthy. Appropriate veterinary monitoring of blood glucose, adjustment of insulin dose and regimen as needed, and stabilization of diet and activity help minimize the risk of hypoglycemic episodes. This product was already approved for use in cats for the same indication. Hypoglycemia can be fatal if an affected animal does not receive prompt treatment. The recommended starting dose in dogs is 0.2-0.5 IU insulin/pound of body weight (0.5-1.0 IU/kg) once daily. K9 Advantix II for Dogs. It is given as an injection under the skin twice daily for cats and once daily for dogs either at the same time or immediately after a meal. ProZinc has not been evaluated for use in humans. Please refer to the Freedom of Information Summary and package insert for ProZinc before using this product. Learn more about managing diabetes at home. Cats 1–2 U per cat q 12 hr. US-PET-0164-2019. Salix (Furosemide) Tablet Rx. Two hundred twenty-four (224) dogs were included in the effectiveness analysis. Can be used in dogs and cats. For more information, see full prescribing information. PROZINC ® (protamine zinc recombinant human insulin), the simple and reliable choice for diabetes control in dogs and cats. Effectiveness was based on successful control of diabetes, which was defined as improvement in at least one laboratory parameter (blood glucose curve mean, blood glucose curve minimum, or fructosamine) and at least one clinical sign (polyuria, polydipsia, or body weight loss). As of February 2019, two insulin products have been approved by the FDA for use in dogs — ProZinc… For more information, please contact CVM’s Education & Outreach Staff at 240-402-7002 or AskCVM@fda.hhs.gov. FDA-approved drugs have been demonstrated to be safe and effective for their intended use. Dogs Nadir 8–12 hr. Diabetic dogs require lifelong insulin treatment to replace the insulin that their pancreas no longer makes, and no single insulin product effectively manages diabetes in every canine patient. “Once-daily dosing with PROZINC is a breakthrough for pet owners with diabetic dogs,” explained Grant Beckett, BVSc MRCVS, senior associate director, Technical Marketing, Boehringer Ingelheim Animal Health. The site is secure. Owners should be advised to observe for signs of hypoglycemia (low blood sugar). Costco Pharmacies now dispense commonly used prescription drugs for your pets at a great value. PROZINC is FDA-approved to reduce hyperglycemia and hyperglycemia-associated clinical signs in dogs 2, and offers: An extended duration of action: pharmacokinetic/pharmacodynamic data demonstrate a duration of action, in both healthy and diabetic dogs, of 16 to >24 hours with once-daily, single site administration of protamine zinc recombinant human insulin 1,2 Now, there are two drug products specifically approved for the management of diabetes mellitus in dogs, ProZinc and Merck Animal Health’s Vetsulin (porcine insulin zinc suspension). Dogs were started on ProZinc at a dose of 0.2-0.5 IU/lb (0.5-1.0 IU/kg) once daily. Now, with two presentations designed for feline and canine patients, PROZINC is the insulin veterinarians have been waiting for. You should re-evaluate the dog at appropriate intervals and adjust the dose and frequency based on both clinical signs and laboratory parameters (mean and minimum blood glucose and fructosamine) until adequate glycemic control has been attained. Proin is an FDA-approved, chewable, liver flavored tablet that is used for the control of urinary leaking in dogs. PROZINC should not be used during episodes of hypoglycemia (low blood sugar). The correct dose is determined individually for each animal depending on weight and needs to be adjusted depending on the response to treatment. PROZINC (protamine zinc recombinant human insulin) is an injectable insulin for cats and dogs. (protamine zinc recombinant human insulin). ProZinc® (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. Pros . Unlike FDA-approved ProZinc, compounded formulations of insulin have not been evaluated by the FDA for safety or effectiveness and may vary in quality and potency. In addition, there has been demonstrated consistency in the manufacturing of FDA-approved products, for example, to preserve the drug’s identity, strength, quality and purity. Starts at $19.99. Reviews: 58. The drug’s safety and effectiveness. The effectiveness of ProZinc was demonstrated in one adequate and well-controlled 84-day clinical field study in client-owned dogs followed by a 98-day extended-use phase with 276 dogs receiving ProZinc. Additional saving can be obtained on both current and new prescriptions with the Costco Member Prescription Program Discount Card (CMPP), a Costco-member-only program for those who have no prescription drug coverage through any insurance plan. That said, it is recommended that dogs be given Proin at: 0.4 to 0.8 mg per pound of the dog’s body weight, *produced by recombinant DNA technology Excipients: Protamine sulfate 0.466 mg ProZinc 40 IU/ml suspension for injection for cats and dogs. With just two daily doses a day in cats and once-a-day dosing in most dogs, delivered before or just after a meal, PROZINC provides fast, effective results for hyperglycemia in pets with diabetes.1,2 Learn more about how to administer PROZINC to your pet. Once-daily dosing can be a reality for the majority of your canine diabetic patients with PROZINC ® (protamine zinc recombinant human insulin). Insulin for Dogs & Cats . U-40. Boehringer Ingelheim Animal Health UK Ltd. Tel: Technical Enquiries: 01344 746957. Improvement can usually be seen within a few days. ProZinc is contraindicated in dogs sensitive to protamine zinc recombinant human insulin or any other ingredients in ProZinc. Before sharing sensitive information, make sure you're on a federal government site. Reviews: 70. ProZinc is the first and only FDA-approved protamine zinc insulin for cats containing human recombinant insulin. QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml contains: Active substance: Insulin human* 40 IU as protamine zinc insulin. ProZinc 40 IU/ml suspension for injection for cats and dogs. Prozinc (Boehringer Ingelheim Animal Health) FDA Approval Status. ProZinc . The most common adverse reactions were lethargy, anorexia, hypoglycemia, vomiting, seizures, shaking, diarrhea, and ataxia. Keep out of the reach of children. Boehringer Ingelheim Animal Health UK Ltd. Telephone: Technical Enquiries: 01344 746957. Dogs 0.25–0.5 U/kg q 12 hr. ProZinc 40 IU/ml suspension for injection for cats and dogs. As part of the approval process, the drug company must prove to the FDA that: The FDA’s role does not stop after the agency approves an animal drug. PROZINC® is a registered trademark of Boehringer Ingelheim Animal Health USA Inc.© 2020 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved. Compounded animal drug preparations are not FDA-approved drugs, nor are they FDA-approved generic drugs. Protamine zinc insulin that is similar to human insulin but costs less. The absorption and effectiveness of ProZinc has been demonstrated. The biggest disadvantage of ProZinc for use in dogs is the relatively high cost of injecting the higher doses of insulin needed. ProZinc (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. The drug should not be given during episodes of hypoglycemia. 1,2 Learn more about how to administer PROZINC to your pet. Now FDA-approved for dogs. "Prozac for dogs is not for problem behaviors or those things your dog does that bug you,” Petryk says. Sometimes, the agency’s post-approval monitoring uncovers safety and effectiveness issues that were unknown at the time of approval; The manufacturing process to ensure quality and consistency are maintained; The drug’s labeling to make sure the information remains truthful and not misleading; and. The drug is safe and effective for a specific use in a specific animal species; The manufacturing process is adequate to preserve the drug’s identity, strength, quality, and purity from lot-to-lot for a consistent product; and. The FDA’s Center for Veterinary Medicine (CVM) is committed to promoting and protecting animal health by ensuring safe and effective drugs are available for animals. Comments. Starting Dose. The company’s marketing communications related to the drug to make sure the information is truthful and not misleading. The FDA strongly encourages use of an FDA-approved veterinary insulin drug product for newly diagnosed diabetic dogs, or when considering transitioning patients from one product to another. PROZINC in Dogs. How PROZINC Helps With just two daily doses a day in cats and once-a-day dosing in most dogs, delivered before or just after a meal, PROZINC provides fast, effective results for hyperglycemia in pets with diabetes. One IU (International Unit) corresponds to 0.0347 mg of insulin human. Each dose should be given concurrently with or right after a meal. Datasheet & Company Info. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. To help you decide whether Prozac is right for your dog, we asked experts to explain how it works, the pros and cons of giving it to canines, potential side effects and more. Manufactured for Boehringer Ingelheim Animal Health Inc., ProZinc is a prescription animal drug product containing 40 international units (IU) insulin/mL and is intended for subcutaneous injection using a U-40 syringe. a sterile aqueous protamine zinc suspension of recombinant human The FDA would like to emphasize the benefits of using FDA-approved drugs in your practice, and of the bioavailability concerns associated with compounded insulin preparations. Reviews: 56. ProZinc is now FDA-approved for use in dogs too. 14. Starts at $15.98. 22. ProZinc is contraindicated in dogs and cats that are sensitive to protamine zinc recombinant human insulin or any other ingredients in ProZinc, according to the FDA. The .gov means it’s official.Federal government websites often end in .gov or .mil. Based on this definition, 162 of 224 cases (72%) were considered successful. IMPORTANT SAFETY INFORMATION: PROZINC is for use in dogs and cats only. 1. Cats Nadir 5–7 hr. In severe cases of hypoglycemia, seizures and coma can occur. ProZinc (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. ProZinc® (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. Peak Action (Nadir) and Duration of Effect. If you suspect your pet may have diabetes, learn more about the signs. ProZinc 40 IU/ml suspension for injection for cats and dogs Normal supply has been restored – vets can place orders via their usual process (updated 11 August 2020) Cats, Dogs 1 Gostelow R, Scudder C, Hazuchova K, et al. Approved in cats. For more information, see full prescribing information. Prozac itself is not approved by the FDA for use in animals but may be prescribed by vets off-label for managing the above-mentioned issues in dogs. The drug’s labeling is truthful and not misleading. Starts at $0.19. This is especially true in larger breed dogs where doses of 30-50 U, bid, might be needed to achieve diabetic control. As long as the drug company markets the animal drug, the agency continues to monitor: ProZinc is contraindicated in dogs sensitive to protamine zinc recombinant human insulin or any other ingredients in ProZinc. PROZINC is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus. ProZinc is contraindicated during episodes of hypoglycemia. Website: www.boehringer … PROZINC is a robust and stable insulin, having undergone thorough stability testing: PROZINC has a 2-year shelf life from date of manufacture 5 PROZINC remains stable even if left at room temperature for short periods of time 5 such as may occur during normal use