Hives, severe rash, or difficulty breathing could be a sign of allergic reaction. For example, a 2015 study gave rats a daily dosage for 40 days of Ipomoea digitata (a flowering herb). Going back to the potential side effects in men, a couple studies actually used neem oil to intentionally cause infertility in male rats. Though neem could be used as an antifertility agent when required, it may also reduce fertility even when not desired (2). Though no direct link had been established between neem intake and kidney damage, it is important to be careful. Note: Unlike chemical sprays that can have immediate but toxic effects, neem oil will not work overnight and will take a few days to show results. This means that the animal models did not show any side effects and their fertility was restored after a few months. These may include: vomiting There have been neem poisoning cases in children involving seizures, coma and death. They are also used as a replacement for a toothbrush helping. There is no research to support this. It can also be used to treat lice. However, there is insufficient information to substantiate this. // Leaf Group Lifestyle, The Safe Amount of Flaxseed Oil for Children, Natural Medicines Comprehensive Database: Neem. Pregnancy/Lactation. Well it was a little windy. Vomiting, lethargy, and loose stools are also symptoms of Reye's Syndrome that can occur within minutes after ingesting neem oil. J Ethnopharmacol. Sue likes the idea of using neem because "it is not chemical" and hasn't seen any negative effects of using it in her garden. Anticancer biology of Azadirachta indica L (neem): a mini review. Antifertility potential of Neem flower extract on adult female Sprague-Dawley rats, African Health Sciences, US National Library of Medicine, National Institutes of Health. However, too much neem oil intake may cause damage to the proper functioning of these organs and result in jaundice and decrease in urine production. He considers himself a sculptor born to chip away at content and reveal its dormant splendor. Doctors recommend small amounts of neem oil for diabetic patients as it controls blood sugar levels. He survived with permanent speech, memory and motor deficits.The Natural Medicines Comprehensive Database does not consider neem to be safe for children. Rare instances of allergic reactions to neem oil … Vomiting, lethargy, and loose stools are also symptoms of Reye's Syndrome that can occur within minutes after ingesting neem oil. Researchers at the University of Singapore conducted a study of the effects of neem oil on mice for the Journal of Pathology in 1989. Benefits as a Skincare Product: Neem is famous for its use in treating redness, itchy skin, and inflamed skin. These serious side effects include vomiting, diarrhea, drowsiness, blood disorders, seizures, loss of consciousness, coma, brain disorders, and death. Neem can be unsafe for adults when used in large amounts or for extended periods. Discontinue use of neem oil immediately and consult a doctor if your conditions persist. (Sources) Some studies suggest that neem should be used with caution. Keep it away from the reach of children, so that they don’t consume it by accident. But that story can change if the use is abused. For most adults, neem is generally safe for topical use on the skin for up to two weeks, when taken by mouth for up to 10 weeks or when applied inside the mouth for up to six weeks. 2015;14:187. doi:10.1186/s12936-015-0705-4. Indian J Dent Res. Traditional Ayurvedic doctors did not advise the use of neem if the person suffers from fatigue. Side Effects of Neem Oil. Loose stools; Vomiting or nausea; Acidosis Well this time I had a small spray bottle with just water and poured over a teaspoon full shook it up really good. A gap of 30 days should be taken in between restarting the internal regimen of neem oil. Children: Taking neem seeds or oil by mouth is LIKELY UNSAFE for children. Neem side effects Since it can lower blood glucose levels, as a general rule, if you’re fasting, it is better to avoid oral intake of neem. Generally, neem oil is considered safe to be used for skincare purposes. While precious lives are often saved with timely medical intervention, there are deaths too. Potential side effects and risks. Phytother Res. For most adults, neem is generally safe for topical use on the skin for up to two weeks, when taken by mouth for up to 10 weeks or when applied inside the mouth for up to six weeks. Kids, infants and toddlers must refrain from consuming neem oil. Neem: A Tree For Solving Global Problems, National Center for Biotechnology Information. Low or no urine production. Neem Juice: 2-4 tsp twice a day. Please advise how it adversely affects humans when breathing it. All rights reserved. Neem soap is made out of neem oil and other natural oils in different quantities. People who have sensitive skin may be more likely to experience itchiness or other irritation. Also, while ingesting trace amounts of neem oil will likely not cause harm, consuming large quantities can cause adverse effects, especially in children. Malar J. 1. Neem Syrup: 3-4 tsp twice a day after meals. Neem Oil Side Effects. However, there is insufficient information in this regard. Learn about this Neem oil usage, dosage, and side effects. Side effects of using neem oil. The substances present in neem are known to cause symptoms of Reye’s syndrome in infants when exposed to neem oil. Azadirachtin, a component of neem oil, can be very irritating to the skin and stomach. Neem had caused 90% deaths at the end of six weeks in rabbits (3). and Gynura procumbens (Lour.) In this article, learn about the uses and benefits of neem, as well as some safety considerations. Neem twigs are used for cough, urinary disorders, and intestinal worms. People with diabetes should use neem only under medical supervision, with constant blood glucose level monitoring. One of the most significant things to be considered is the use of diluted neem oil only. As an allergic reaction, the side effects may include rash, irritation, or breathing problem. Neem Capsule/ Tablet: 1-2 tablets or capsules twice a day. Cancer Biol Ther. A 2008 report in Indian Pediatrics described the use of neem oil to treat colds by placing drops of neem oil in the nose. https://www.semanticscholar.org/paper/Allergic-contact-stomatitis-caused-by-neem-leaves-Ambooken-Abdulsalam/04ad81d7a1bf26267056728dc5b56174085b7863, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583274/, https://www.ncbi.nlm.nih.gov/books/NBK234639/, https://www.ncbi.nlm.nih.gov/pubmed/9228306, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496464/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312413/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838201/, https://link.springer.com/article/10.1007/s12098-013-1327-x, https://www.ncbi.nlm.nih.gov/pubmed/3419203, https://www.ncbi.nlm.nih.gov/books/NBK234637/, https://www.ncbi.nlm.nih.gov/pubmed/6110100/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061674/, How To Stop Being Clingy In A Relationship, Apple Cider Vinegar For Diabetes: How To Use, 30 Wonderful Benefits Of Hazelnuts For Skin, Hair And Health, 12 Potential Health Benefits Of Chyawanprash, Apple Cider Vinegar: 8 Possible Side Effects And Dosage, Coconut Oil Side Effects: High Cholesterol, Diarrhea, And More, 9 Amazing Health Benefits Of Uva-Ursi For Skin, Hair And Health, 14 Best Benefits Of Red Grapes For Skin, Hair And Health, 10 Serious Side Effects Of Sleeping Pills, Tea Tree Oil For Warts: Benefits, How To Use, And More, 10 Research-Backed Benefits Of Coconut Water For Your Health And Skin, 21 Best Benefits Of Eating Watermelon For Skin, Hair, And Health. My side effects after spraying Neem Oil by: Parsons.T I use Neem Oil Insecticide Spray. A January 2009 study published in Einstein summarized the effects of neem oil on the ovaries of mice. Side Effects Of Neem. Anecdotal evidence suggests that one to two leaves a day could be fine. Comparative Evaluation of Neem Mouthwash on Plaque and Gingivitis: A Double-blind Crossover Study. Some theories state that overexposure to neem may cause the immune system to become hyperactive. Studies have shown that neem could be toxic to infants. However, it can be quiet unhealthy if taken by mouth. Azadirachtin, a complex tetranortriterpenoid, is implicated in causing the effects seen in neem oil poisoning. According to the Natural Medicines Comprehensive Database, neem has contraceptive properties and causes miscarriage. Research reveals little or no adverse reactions in adults with the use of neem at normal doses. Exact toxic dose levels of neem oil are not known. Difficulty breathing. Neem oil is deemed an “organic pesticide” as it comes from the vegetable oil of seed kernels from the neem tree (Azadirachta indica). Tiffany Adams is a health and fitness writer. The use of neem for controlling gastric hyperacidity and ulcer. 2011;12(6):467-76. doi:10.4161/cbt.12.6.16850, Abiy E, Gebre-michael T, Balkew M, Medhin G. Repellent efficacy of DEET, MyggA, neem (Azedirachta indica) oil and chinaberry (Melia azedarach) oil against Anopheles arabiensis, the principal malaria vector in Ethiopia. May Cause Allergic Reactions A study discusses a case of allergic contact stomatitis (inflammation of the mouth)... 2. Neem leaves or their extracts must not be consumed for longer periods. Information regarding safety and efficacy in pregnancy and lactation is lacking. Margosa oil poisoning as a cause of Reye’s syndrome, Lancet, US National Library of Medicine, National Institutes of Health. Though neem has been of recognizable significance in the field of haircare yet there are some possible side effects which are likely to be observed post topical application. Caution & Side Effects. We described the ultrastructure of Ceraeochrysa claveri (Navás) midgut endocrine cells in larva, pupa, and adult, and evaluated the side effects of ingested neem oil, a botanical insecticide obtained from the seeds of the neem tree (Azadirachta indica), on these cells. Acute toxicity study of the oil from Azadirachta indica seed (neem oil), Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. This could lead the body to reject the sperm cells and eject them from the conceived embryo. Neem oil can also cause irritation in the eyes and the skin in some people. Like any other ingredients, make sure you patch test first, to make sure you don’t get an allergic reaction. However, there have been reports of neem poisoning. Another common side effect that you can experience with the consumption of neem leaf is an increase in fatigue. Neem: Benefits, Uses, Formulation, Ingredients, Dosage And Side Effects September 23, 2020 Fondly touted as the “Panacea For All Diseases”, the health benefits of the bitter neem leaves in any form have been employed for various purposes for centuries now. Neem oil has a lot of benefits and is obviously good and has positive effect on kidney and liver functioning due to its antioxidant features. Toxicology You can learn more about how we ensure our content is accurate and current by reading our. Copyright © 2021 Leaf Group Ltd., all rights reserved. Merr. Neem oil applied to the skin is typically touted as safe, with many studies claiming that there were no side effects whatsoever–although such claims should always be viewed with healthy skepticism [34+, 14, 35+]. Researchers at the University of Singapore conducted a study of the effects of neem oil on mice for the Journal of Pathology in 1989. Reading and theater are his other interests. Avoid use. A January 2009 study published in Einstein summarized the effects of neem oil on the ovaries of mice. Azadirachtin, a component of neem oil, can be very irritating to the skin and stomach. Allergic reaction like rash, itching, swelling of the throat or mouth, wheezing. She is pursuing her bachelor's degree in nursing. Is neem oil harmful to humans? Powdery mildew is a fungal disease that affects many plants and especially roses. However, it can be … They are discussed in the next section. 2004;90(1):99-103. doi:10.1016/j.jep.2003.09.035, Almas K. The antimicrobial effects of extracts of Azadirachta indica (Neem) and Salvadora persica (Arak) chewing sticks. Neem oil, is a vegetable oil, which is pressed from the seeds of neem and fruits. Several neem extracts did show negative side effects when fed to laboratory … Neem leaves are used to treat leprosy, eye ailments, upset stomach, and liver problems. It has been used extensively in ancient Ayurvedic medicine. We need more research to further understand the other allergies the use of neem may cause. Risks and Side Effects. Click here for additional information . Hypoglycemic Effect of Combination of Azadirachta indica A. Juss. NOTE: Pregnant women, women trying to conceive, and children may be more sensitive to neem oil and are advised to avoid using it. Neem oil induced fatty liver damage and brain swelling in a state similar to Reye's Syndrome--a disease associated with viral illness in children and teens. Allergic contact stomatitis caused by neem leaves (Azadirachta indica), Semantic Scholar. Ethanolic Extracts Standardized by Rutin and Quercetin in Alloxan-induced Hyperglycemic Rats, Advanced Pharmaceutical Bulletin, US National Library of Medicine, National Institutes of Health. Since some individuals experience allergic reactions to neem oil, it's important to discontinue use of the oil if you experience symptoms such as itching or reddening of the skin. The mice were given neem oil at low and high doses for six weeks. Anupama November 9, 2017 June 21, 2019. There is less information to state the ideal dosage of neem. Serious side effects in infants and small children can happen within hours after taking neem oil. 3. … If you have sensitive skin, the neem oil side effects would mostly affect you. Neem can be unsafe for adults when used in large amounts or for extended periods. Allergic reactions to neem can include itchy rash. By doing so, a healthy skin glow is achieved. A study discusses a case of allergic contact stomatitis (inflammation of the mouth) after the intake of neem leaves once every week for three consecutive weeks (1). The use of oral neem oil in children cannot be supported due to reported deaths. 1. Written by Tiffany Adams . Anecdotal reports state kidney failure in patients who consumed neem leaf teas as a treatment for malaria (10). It is the percentage of this component that tells how good is the neem carrier oil for you. Be patient and the results will show! 16. Interactions. Going back to the potential side effects in men, a couple studies actually used neem oil to intentionally cause infertility in male rats. It causes the adverse reaction and might even lead to skin disorder like eczema. However, if you experience any of these side effects after ingesting neem, please stop use and consult your doctor. However, neem didn’t seem to stop sperm production (3). Neem oil poisoning results in vomiting, seizures, metabolic acidosis, and … Neem is among the more important plants used in Ayurvedic medicine. A study reports of a case of acute renal failure in an individual after taking a Chinese herbal medication. Is neem oil safe? In humans, consumption of neem oil is known to cause indigestion which in turn causes vomiting, drowsiness, respiratory difficulty, and seizures. Several small studies into neem side effects showed different results. Yes, you may. Risk of encephalopathy. Neem is used in Ayurvedic and homeopathic medicine to treat conditions such as peptic ulcer disease and tooth decay. The medication, as per the report, contained neem as one of the primary ingredients (5). So, if you want to learn the potential benefits of applying neem oil directly on the hair, stick around, and enjoy reading. If you are unsure about what type of skin you have or if you are using the neem oil for the first time, it is best to try the diluted form of neem oil on a small patch of skin. The following two tabs change content below. It is bitter and non-edible. In studies done on rats, mice, rabbits, and guinea pigs, neem was found to reduce male fertility. The juice of the leaf is one of the most effective toners and astringents. Before we proceed, let have a look at what neem oil really looks like, the tree, leaves, seeds, and oils. Although neem oil is considered safe for mankind, because of its powerful compounds, it may cause side effects in people with the following conditions: Pregnancy – Neem oil may cause miscarriage If it’s taken orally during pregnancy. The Neem oil is a vegetable oil extracted from the fruits and seeds of the Neem tree. Although few scientific studies have tested the health effects of neem, He graduated from SRM University, Chennai, and has been in the digital media field for over six years. The remaining portion of neem oil is made of fatty acids, essential oils and other substances that are commonly eaten in a normal diet. The oral use of neem oil can cause following side effects. 2017;18(7):567-571. doi:10.5005/jp-journals-10024-2085, Pai MR, Acharya LD, Udupa N. Evaluation of antiplaque activity of Azadirachta indica leaf extract gel--a 6-week clinical study. The consumption of the smallest dosage can be fatal for infants (11). Consult a physician before using any naturopathic treatment. 1 Neem Oil Ingredients; In this post, we have discussed the possible side effects of neem leaves and the possible right dosage. Using the soap containing atleast 20% of the neem oil content is good for the skin. The plant is often confused with Melia azedarach L., the chinaberry or Persian lilac. Neem oil is a carrier oil extracted from the neem (Azadirachta indica), a tree native to Sri Lanka, Burma, and India, and now grown in tropical regions around the world. When ingested by humans, Neem oil causes vomiting and drowsiness. But to be on the safe side, if you have liver issues, please consult your doctor before consuming neem. Side Effects of Neem OilIf you’re overweight, and dieting and exercise haven't worked for you. Another in vivo (animal based) study revealed that application of neem oil through the vagina immobilized sperms within seconds. Yellow skin (jaundice). Hypoglycemia may cause dizziness and weakness (fatigue) (7). The ingestion or topical application of neem, which is an evergreen tree traditionally used as medicine in ayurvedic practices, can cause side effects such as liver and kidney damage, allergic reactions and Reye’s Syndrome. Research even shows that Neem acts as an antipyretic agent and protect the liver from the side effects of malaria. Neem may cause eye irritation. The flower is used for reducing bile, controlling phlegm, and treating intestinal worms. We avoid using tertiary references. Preclinical studies suggest that administering neem oil within the uterus induces reversible fertility. The external application of neem oil is LIKELY SAFE and WELL-TOLERATED in most of people. The fruit is used for treating hemorrhoids, phlegm, wounds, and diabetes. Table of Contents. However, research is lacking in this aspect. For example, a 2015 study gave rats a daily dosage for 40 days of Ipomoea digitata (a flowering herb). Health Benefits of Neem Oil, Uses And Its Side Effects Neem Oil. Whether it is neem oil, neem paste or neem leaves, the doctor’s consultation is a must. Those with kidney and liver diseases cannot use it without the permission of the doctor. More research is needed to understand how this happens. A five-year-old boy suffered severe seizures an hour after after swallowing neem oil which resulted in cardiac arrest. The common side effects of DEET include skin rashes and irritation. Ravi Teja Tadimalla is an editor and a published author. There is neem oil, neem leaves, neem bark, neem flowers. The bark is primarily used for malaria, ulcers, and fever. The oral use of neem oil can cause following side effects. You can use it as an insect repellant by applying diluted neem oil to the skin, burning a neem candle or incense, or mixing neem oil with kerosene (in a 1:100 ratio) in an oil lamp or lantern. Risks and Side Effects. However, a study states a case of optic neuropathy in an individual after consuming neem oil (12). Neem oil can be slightly irritating to the eyes and skin. A 2008 report in Indian Pediatrics described the use of neem oil to treat colds by placing drops of neem oil in the nose. Leaves grow alternately with leaflets containing 8 to 19 leaves. However, experts advise against the use of heavy doses of neem (especially in patients with ailments). But, when taken in excess, the drop may become extreme. However, people rarely come across such signs. Neem oil induced fatty liver damage and brain swelling in a state similar to Reye's Syndrome--a disease associated with viral illness in children and teens. Other serious side effects observed include drowsiness and brain swelling. Exact toxic dose levels of neem oil are not known. Destruction of red blood cells. None well documented. May Lead To Reduced Fertility In rat studies, the administration of neem flower extracts blocked ovulation partially. StyleCraze provides content of general nature that is designed for informational purposes only. Neem Oil (Nimb Tail) Usage and Side Effects Know about Neem oil ingredients and health condition in which Neem oil is useful. Neem is used in Ayurvedic and homeopathic medicine to treat conditions such as peptic ulcer disease and tooth decay. They wanted to see if it could improve/reverse things for “neem-oil induced infertile rats” . It should also be noted that The extracts could terminate a pregnancy with no visible side effects in both rodents and monkeys. Intake of neem may be safe for your eyes. It is available as an oil or extract. The leaves are believed to interact with immunosuppressant medications during surgeries. 28 November, 2018 . Neem oil should not be consumed orally. Most of its benefits have been extensively researched. Excess inhalation or consumption of neem may cause indigestion or stomach irritation. He started his career as a research writer, primarily focusing on health and wellness, and has over 250 articles to his credit. Several neem extracts did show negative side effects when fed to laboratory rats in daily high doses over an extended period of time. I've been told that breathing neem oil can cause lightheadedness and dizziness. Neem is a tree whose different parts are used for different medicinal purposes. BREAKTHROUGHS IN POPULATION CONTROL?, Neem: A Tree For Solving Global Problems, National Center for Biotechnology Information. Liver damage. In children, neem oil is reported to cause toxic encephalopathy and Reye’s–like syndrome. Preclinical studies suggest that administering neem oil within the uterus induces reversible fertility. The oil is used as a pesticide and as an ingredient is cosmetics. Some experts theorize that farmers use neem pesticides to cause infertility in the pests so that they do not multiply, resulting the same in individuals who expose themselves to these pesticides. Though the contaminants in neem oil could be responsible for these effects (and not neem itself), more research is warranted. People with diabetes should use neem only under medical supervision, with constant blood glucose level monitoring. According to the Natural Medicines Comprehensive Database, nimbolide in the neem seed oil acts to fight bacteria and malaria--an infectious disease transmitted by mosquitoes. The tree yields There have been neem poisoning cases in children involving seizures, coma and death. No studies to date have shown adverse effects for topical uses of neem oil, leaves, or bark. As the soap includes the neem oil, it soothes dry and itchy skin. The possible side effects of neem included: Kidney damage. These serious side effects include vomiting, diarrhea, drowsiness, blood disorders, seizures, loss of consciousness, coma, brain disorders, and death. They wanted to see if it could improve/reverse things for “neem-oil induced infertile rats” . What are the Neem Oil Side Effects? Do not consume neem oils, or it can cause a lot of different toxic side effects including loss of consciousness or severe stomach problems. RSSDI clinical practice recommendations for the management of type 2 diabetes mellitus 2017, International Journal of Diabetes in Developing Countries, US National Library of Medicine, National Institutes of Health. Potential side effects and risks Diluted neem oil is generally considered safe to use topically. Neem Oil Side Effects & Some Useful Tips. For most adults, neem is generally safe for topical use on the skin for up to two weeks, when taken by mouth for up to 10 weeks or when applied inside the mouth for up to six weeks. Neem Oil for Powdery Mildew. Animal studies also showed the toxicity of neem oil at doses as low as 12 to 24 mL per kilogram of body weight (9). PubMed: Animal Model of Margosa Oil Ingestion with Reye-like Syndrome... Einstein: Effect of Neem Oil on the Structure and Function of the Mature Female Albino Rat Ovaries, Jalaluddin M, Rajasekaran UB, Paul S, Dhanya RS, Sudeep CB, Adarsh VJ. The neem (formerly known as Melia azadirachta L.) is a large evergreen tree that grows up to 20 m in height, with spreading branches that form a broad crown. J Contemp Dent Pract. Posted by Corey (Topeka, Kansas) on 11/01/2017. Neem Side Effects: Although it is considered safe when consumed in measured quantities as per the instructions of an ayurvedic doctor or practitioner. Patients who have undergone organ transplants may also need to stay away from neem. In today’s post, you’re going to learn “how to prepare neem oil for hair growth,” and know whether or not “can we apply neem oil directly on hair.”. He has a Professional Certificate in Food, Nutrition & Research from Wageningen University. Though neem is most commonly used for treating allergies and rashes, its excessive use may lead to allergies. A 2015 study in Malaria Journal found a 20% neem formula is more than 70% effective against mosquitos and that the protection lasts about three hours. The trend of toxic renal injuries with respect to herbal medicines is likely to continue (5). The main concern with overuse is it may harm the liver or kidneys. From centuries, Neem oil for eczema has been considered as a very good remedy, along with that, neem leaves have also been used for the treatment of eczema and dry skin as well as other skin issues including wound healing, acne and bug bites. Neem Oil Poisoning as a Cause of Toxic Encephalopathy in an Infant, The Indian Journal of Pediatrics. Neem is an evergreen tree native to the Indian subcontinent. Side Effects. In such patients, neem may overstimulate their immune system and cause complications. AZADIRACTIN, the determinant of Neem carrier oil quality is used as a natural pesticide. What Are The Side Effects Of Neem Leaves? Consuming a couple of drops of neem oil every day can do wonders and provide you healthy lungs. They are known to disrupt the direction of the sperms and take a toll on the immune system. Generally, neem oil is considered safe to be used for skincare purposes. Neem comes from the Indian lilac tree. However, excess use of its leaves has been linked to side effects. The remaining portion of neem oil is made of fatty acids, essential oils and other substances that are commonly eaten in a normal diet. The external application of neem oil is LIKELY SAFE and WELL-TOLERATED in most of people. Neem oil can be slightly irritating to the eyes and skin. These have only been validated by anecdotal evidence. Researchers surmised that accidental ingestion of neem oil can occur this way. Induced termination of pregnancy by purified extracts of Azadirachta Indica (Neem): mechanisms involved, American Journal of Reproductive Immunology, US National Library of Medicine, National Institutes of Health. Acute Renal Failure Induced by Chinese Herbal Medication in Nigeria, Case Reports in Medicine, US National Library of Medicine, National Institutes of Health. In animal studies, extracts of neem were found to induce pregnancy. Therefore, if you feel these symptoms you should avoid neem oil … Azadirachtin (tetranortriterpenoid) found in neem oil sometimes cause poisoning with symptoms like vomiting, seizures, metabolic acidosis, and toxic encephalopathy. I tried holding my breath every time I spray it. In other studies there were no side effects at all from neem products, including neem oil, even when using large amounts, and over several generations.